Microbiota, Adaptive, and Innate Mucosal Immunity
نویسندگان
چکیده
منابع مشابه
Innate and adaptive immunity in host-microbiota mutualism.
Healthy individuals live in peaceful co-existence with an immense load of intestinal bacteria. This symbiosis is advantageous for both the host and the bacteria. For the host it provides access to otherwise undigestible nutrients and colonization resistance against pathogens. In return the bacteria receive an excellent nutrient habitat. The mucosal immune adaptations to the presence of this com...
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A large mucosal immune system controlled by unique, organ-specific regulations operates alongside and separate from the peripheral or systemic immune system. This local immune system is seen as a major interface between the innate and the specific immune system. We have been interested in the immunopathogenesis of a chronic inflammatory bowel disease (IBD) developing in CD4+ T cell-transplanted...
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We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative a...
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The term "microbiota" means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such ...
متن کاملBridging Innate and Adaptive Immunity
The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunology, the evolutionarily ancient innate immune response and modern adaptive immunity.
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2011
ISSN: 1664-3224
DOI: 10.3389/conf.fimmu.2011.01.00001